diff --git a/package/python-setuptools/Config.in b/package/python-setuptools/Config.in
index 63c2b01817..c72c59fbc8 100644
--- a/package/python-setuptools/Config.in
+++ b/package/python-setuptools/Config.in
@@ -1,7 +1,9 @@
 config BR2_PACKAGE_PYTHON_SETUPTOOLS
 	bool "python-setuptools"
-	depends on BR2_PACKAGE_PYTHON
-	select BR2_PACKAGE_PYTHON_ZLIB
+	select BR2_PACKAGE_PYTHON_ZLIB if BR2_PACKAGE_PYTHON # runtime
+	select BR2_PACKAGE_PYTHON3_ZLIB if BR2_PACKAGE_PYTHON3 # runtime
+	select BR2_PACKAGE_PYTHON_PYEXPAT if BR2_PACKAGE_PYTHON # runtime
+	select BR2_PACKAGE_PYTHON3_PYEXPAT if BR2_PACKAGE_PYTHON3 # runtime
 	help
 	  Download, build, install, upgrade, and uninstall Python packages.