diff --git a/package/gcc/gcc.mk b/package/gcc/gcc.mk
index dff6dce466..32219cc3db 100644
--- a/package/gcc/gcc.mk
+++ b/package/gcc/gcc.mk
@@ -125,6 +125,11 @@ ifneq ($(BR2_TOOLCHAIN_BUILDROOT_WCHAR),y)
 HOST_GCC_COMMON_CONF_OPT += --disable-libquadmath
 endif
 
+# libsanitizer requires wordexp, not in default uClibc config
+ifeq ($(BR2_TOOLCHAIN_BUILDROOT_UCLIBC),y)
+HOST_GCC_COMMON_CONF_OPT += --disable-libsanitizer
+endif
+
 ifeq ($(BR2_GCC_ENABLE_TLS),y)
 HOST_GCC_COMMON_CONF_OPT += --enable-tls
 else