diff --git a/package/gcc/gcc.mk b/package/gcc/gcc.mk
index c971151b36..464e4c98e2 100644
--- a/package/gcc/gcc.mk
+++ b/package/gcc/gcc.mk
@@ -116,6 +116,11 @@ ifeq ($(BR2_sparc_v8)$(BR2_sparc_leon3),y)
 HOST_GCC_COMMON_CONF_OPTS += --disable-libitm
 endif
 
+# libmpx uses secure_getenv and struct _libc_fpstate not present in musl
+ifeq ($(BR2_TOOLCHAIN_BUILDROOT_MUSL)$(BR2_TOOLCHAIN_GCC_AT_LEAST_6),yy)
+HOST_GCC_COMMON_CONF_OPTS += --disable-libmpx
+endif
+
 # quadmath support requires wchar
 ifeq ($(BR2_USE_WCHAR)$(BR2_TOOLCHAIN_HAS_LIBQUADMATH),yy)
 HOST_GCC_COMMON_CONF_OPTS += --enable-libquadmath