diff --git a/package/circus/Config.in b/package/circus/Config.in
index e696f251df..3df41f5f23 100644
--- a/package/circus/Config.in
+++ b/package/circus/Config.in
@@ -4,6 +4,7 @@ config BR2_PACKAGE_CIRCUS
 	depends on BR2_USE_WCHAR # pyzmq -> zeromq
 	depends on BR2_INSTALL_LIBSTDCPP # pyzmq -> zeromq
 	depends on BR2_TOOLCHAIN_HAS_THREADS # pyzmq -> zeromq
+	depends on !BR2_TOOLCHAIN_USES_MUSL # python-psutil
 	select BR2_PACKAGE_PYTHON_IOWAIT # runtime
 	select BR2_PACKAGE_PYTHON_PSUTIL # runtime
 	select BR2_PACKAGE_PYTHON_PYZMQ # runtime
@@ -15,7 +16,7 @@ config BR2_PACKAGE_CIRCUS
 
 	  https://circus.readthedocs.org/en/latest/
 
-comment "circus needs Python and a toolchain w/ C++, wchar, threads"
+comment "circus needs Python and a uClibc or glibc toolchain w/ C++, wchar, threads"
 	depends on !BR2_INSTALL_LIBSTDCPP || !BR2_USE_WCHAR || \
-		!BR2_TOOLCHAIN_HAS_THREADS || \
+		!BR2_TOOLCHAIN_HAS_THREADS || BR2_TOOLCHAIN_USES_MUSL \
 		!(BR2_PACKAGE_PYTHON || BR2_PACKAGE_PYTHON3)
diff --git a/package/python-crossbar/Config.in b/package/python-crossbar/Config.in
index be8332515e..7ef1aadbc9 100644
--- a/package/python-crossbar/Config.in
+++ b/package/python-crossbar/Config.in
@@ -1,5 +1,6 @@
 config BR2_PACKAGE_PYTHON_CROSSBAR
 	bool "python-crossbar"
+	depends on !BR2_TOOLCHAIN_USES_MUSL # python-psutil
 	# All the following dependencies are runtime dependencies
 	select BR2_PACKAGE_PYTHON_AUTOBAHN
 	select BR2_PACKAGE_PYTHON_CBOR
@@ -39,5 +40,5 @@ config BR2_PACKAGE_PYTHON_CROSSBAR
 
 	  https://pypi.python.org/pypi/crossbar
 
-comment "python-crossbar needs a toolchain w/ C++"
-	depends on !BR2_INSTALL_LIBSTDCPP
+comment "python-crossbar needs a uClibc or glibc toolchain w/ C++"
+	depends on !BR2_INSTALL_LIBSTDCPP || BR2_TOOLCHAIN_USES_MUSL
diff --git a/package/python-psutil/Config.in b/package/python-psutil/Config.in
index c64eeeed64..0b1333cf5c 100644
--- a/package/python-psutil/Config.in
+++ b/package/python-psutil/Config.in
@@ -1,8 +1,13 @@
 config BR2_PACKAGE_PYTHON_PSUTIL
 	bool "python-psutil"
+	# sys/sysinfo.h conflict with kernel headers
+	depends on !BR2_TOOLCHAIN_USES_MUSL
 	help
 	  psutil is a cross-platform library for retrieving
 	  information on running processes and system utilization
 	  (CPU, memory, disks, network) in Python.
 
 	  https://pypi.python.org/pypi/psutil
+
+comment "python-psutil needs a uClibc or glibc toolchain"
+	depends BR2_TOOLCHAIN_USES_MUSL