diff --git a/package/python3/python3.mk b/package/python3/python3.mk
index 812b0a7317..3b0155079d 100644
--- a/package/python3/python3.mk
+++ b/package/python3/python3.mk
@@ -142,6 +142,10 @@ define PYTHON3_REMOVE_USELESS_FILES
 		-type f -not -name pyconfig.h -a -not -name Makefile` ; do \
 		rm -f $$i ; \
 	done
+	rm -rf $(TARGET_DIR)/usr/lib/python$(PYTHON3_VERSION_MAJOR)/__pycache__/
+	rm -rf $(TARGET_DIR)/usr/lib/python$(PYTHON3_VERSION_MAJOR)/lib-dynload/sysconfigdata/__pycache__
+	rm -rf $(TARGET_DIR)/usr/lib/python$(PYTHON3_VERSION_MAJOR)/collections/__pycache__
+	rm -rf $(TARGET_DIR)/usr/lib/python$(PYTHON3_VERSION_MAJOR)/importlib/__pycache__
 endef
 
 PYTHON3_POST_INSTALL_TARGET_HOOKS += PYTHON3_REMOVE_USELESS_FILES