diff --git a/package/python-brotli/python-brotli.mk b/package/python-brotli/python-brotli.mk
index 745255f413..2ec549ed0c 100644
--- a/package/python-brotli/python-brotli.mk
+++ b/package/python-brotli/python-brotli.mk
@@ -11,6 +11,14 @@ PYTHON_BROTLI_SETUP_TYPE = setuptools
 PYTHON_BROTLI_LICENSE = MIT
 PYTHON_BROTLI_LICENSE_FILES = LICENSE
 
+PYTHON_BROTLI_CFLAGS = $(TARGET_CFLAGS)
+
+ifeq ($(BR2_TOOLCHAIN_HAS_GCC_BUG_68485),y)
+PYTHON_BROTLI_CFLAGS += -O0
+endif
+
+PYTHON_BROTLI_ENV = CFLAGS="$(PYTHON_BROTLI_CFLAGS)"
+
 define PYTHON_BROTLI_EXTRACT_CMDS
 	$(UNZIP) -d $(@D) $(PYTHON_BROTLI_DL_DIR)/$(PYTHON_BROTLI_SOURCE)
 	mv $(@D)/Brotli-$(PYTHON_BROTLI_VERSION)/* $(@D)