diff --git a/supervisor/store/__init__.py b/supervisor/store/__init__.py
index 7266a8f78..f6d33025c 100644
--- a/supervisor/store/__init__.py
+++ b/supervisor/store/__init__.py
@@ -4,7 +4,7 @@ import logging
 
 from ..const import URL_HASSIO_ADDONS
 from ..coresys import CoreSys, CoreSysAttributes
-from ..exceptions import StoreGitError, StoreJobError, StoreNotFound
+from ..exceptions import StoreError, StoreGitError, StoreJobError, StoreNotFound
 from ..jobs.decorator import Job, JobCondition
 from ..resolution.const import ContextType, IssueType, SuggestionType
 from .addon import AddonStore
@@ -115,6 +115,13 @@ class StoreManager(CoreSysAttributes):
         # Delete stale repositories
         for url in old_rep - new_rep - BUILTIN_REPOSITORIES:
             repository = self.get_from_url(url)
+            if repository.slug in (
+                addon.repository for addon in self.sys_addons.installed
+            ):
+                raise StoreError(
+                    f"Can't remove '{repository.source}'. It's used by installed add-ons",
+                    logger=_LOGGER.error,
+                )
             await self.repositories.pop(repository.slug).remove()
             self.sys_config.drop_addon_repository(url)
 
diff --git a/tests/fixtures/add-on.json b/tests/fixtures/add-on.json
index d98812089..61c094040 100644
--- a/tests/fixtures/add-on.json
+++ b/tests/fixtures/add-on.json
@@ -1,10 +1,13 @@
 {
   "advanced": false,
-  "arch": ["amd64"],
+  "arch": [
+    "amd64"
+  ],
+  "slug": "test",
   "description": "Test add-on",
   "location": "tmp_path",
   "name": "Test Add-on",
-  "repository": "https://github.com/awesome-developer/awesome-repo",
+  "repository": "a474bbd1",
   "stage": "stable",
   "version": "1.0.0"
 }
\ No newline at end of file
diff --git a/tests/store/test_custom_repository.py b/tests/store/test_custom_repository.py
index e276f6531..aaa707322 100644
--- a/tests/store/test_custom_repository.py
+++ b/tests/store/test_custom_repository.py
@@ -4,6 +4,8 @@ from unittest.mock import patch
 
 import pytest
 
+from supervisor.addons.addon import Addon
+from supervisor.exceptions import StoreError
 from supervisor.resolution.const import SuggestionType
 from supervisor.store import BUILTIN_REPOSITORIES
 
@@ -72,3 +74,17 @@ async def test_preinstall_valid_repository(coresys, store_manager):
         await store_manager.update_repositories(BUILTIN_REPOSITORIES)
         assert store_manager.get("core").validate()
         assert store_manager.get("local").validate()
+
+
+@pytest.mark.asyncio
+async def test_remove_used_repository(coresys, store_manager, store_addon):
+    """Test removing used custom repository."""
+    coresys.addons.data.install(store_addon)
+    addon = Addon(coresys, store_addon.slug)
+    coresys.addons.local[addon.slug] = addon
+
+    with pytest.raises(
+        StoreError,
+        match="Can't remove 'https://github.com/awesome-developer/awesome-repo'. It's used by installed add-ons",
+    ):
+        await store_manager.update_repositories([])