diff --git a/supervisor/core.py b/supervisor/core.py
index 93f546530..fa5a5ba56 100644
--- a/supervisor/core.py
+++ b/supervisor/core.py
@@ -48,6 +48,12 @@ class Core(CoreSysAttributes):
                 "Docker version %s is not supported by Supervisor!",
                 self.sys_docker.info.version,
             )
+        elif self.sys_docker.info.inside_lxc:
+            self.healthy = False
+            _LOGGER.critical(
+                "Detected Docker running inside LXC. Running Home Assistant with the Supervisor on LXC is not supported!"
+            )
+
         self.sys_docker.info.check_requirements()
 
         # Check if system is healthy
diff --git a/supervisor/docker/__init__.py b/supervisor/docker/__init__.py
index a488ba2be..7f9361ae0 100644
--- a/supervisor/docker/__init__.py
+++ b/supervisor/docker/__init__.py
@@ -2,6 +2,7 @@
 from contextlib import suppress
 from ipaddress import IPv4Address
 import logging
+from pathlib import Path
 from typing import Any, Dict, Optional
 
 import attr
@@ -46,6 +47,11 @@ class DockerInfo:
 
         return version_local >= version_min
 
+    @property
+    def inside_lxc(self) -> bool:
+        """Return True if the docker run inside lxc."""
+        return Path("/dev/lxd/sock").exists()
+
     def check_requirements(self) -> None:
         """Show wrong configurations."""
         if self.storage != "overlay2":