diff --git a/supervisor/addons/model.py b/supervisor/addons/model.py
index a2c6bd7a0..d0c6601fa 100644
--- a/supervisor/addons/model.py
+++ b/supervisor/addons/model.py
@@ -535,7 +535,9 @@ class AddonModel(CoreSysAttributes, ABC):
 
         # Machine / Hardware
         machine = config.get(ATTR_MACHINE)
-        if machine and self.sys_machine not in machine:
+        if machine and f"!{self.sys_machine}" in machine:
+            return False
+        elif machine and self.sys_machine not in machine:
             return False
 
         # Home Assistant
diff --git a/supervisor/addons/validate.py b/supervisor/addons/validate.py
index 68b232601..03f2747bd 100644
--- a/supervisor/addons/validate.py
+++ b/supervisor/addons/validate.py
@@ -120,7 +120,10 @@ V_LIST = "list"
 
 RE_SCHEMA_ELEMENT = re.compile(
     r"^(?:"
-    r"|bool|email|url|port"
+    r"|bool"
+    r"|email"
+    r"|url"
+    r"|port"
     r"|str(?:\((?P<s_min>\d+)?,(?P<s_max>\d+)?\))?"
     r"|password(?:\((?P<p_min>\d+)?,(?P<p_max>\d+)?\))?"
     r"|int(?:\((?P<i_min>\d+)?,(?P<i_max>\d+)?\))?"
@@ -148,24 +151,25 @@ RE_DOCKER_IMAGE_BUILD = re.compile(
 
 SCHEMA_ELEMENT = vol.Match(RE_SCHEMA_ELEMENT)
 
-
-MACHINE_ALL = [
-    "intel-nuc",
-    "odroid-c2",
-    "odroid-n2",
-    "odroid-xu",
-    "qemuarm-64",
-    "qemuarm",
-    "qemux86-64",
-    "qemux86",
-    "raspberrypi",
-    "raspberrypi2",
-    "raspberrypi3-64",
-    "raspberrypi3",
-    "raspberrypi4-64",
-    "raspberrypi4",
-    "tinker",
-]
+RE_MACHINE = re.compile(
+    r"^!?(?:"
+    r"|intel-nuc"
+    r"|odroid-c2"
+    r"|odroid-n2"
+    r"|odroid-xu"
+    r"|qemuarm-64"
+    r"|qemuarm"
+    r"|qemux86-64"
+    r"|qemux86"
+    r"|raspberrypi"
+    r"|raspberrypi2"
+    r"|raspberrypi3-64"
+    r"|raspberrypi3"
+    r"|raspberrypi4-64"
+    r"|raspberrypi4"
+    r"|tinker"
+    r")$"
+)
 
 
 def _simple_startup(value) -> str:
@@ -185,7 +189,7 @@ SCHEMA_ADDON_CONFIG = vol.Schema(
         vol.Required(ATTR_SLUG): vol.Coerce(str),
         vol.Required(ATTR_DESCRIPTON): vol.Coerce(str),
         vol.Required(ATTR_ARCH): [vol.In(ARCH_ALL)],
-        vol.Optional(ATTR_MACHINE): [vol.In(MACHINE_ALL)],
+        vol.Optional(ATTR_MACHINE): vol.All([vol.Match(RE_MACHINE)], vol.Unique()),
         vol.Optional(ATTR_URL): vol.Url(),
         vol.Required(ATTR_STARTUP): vol.All(_simple_startup, vol.Coerce(AddonStartup)),
         vol.Required(ATTR_BOOT): vol.In([BOOT_AUTO, BOOT_MANUAL]),
diff --git a/tests/addons/test_config.py b/tests/addons/test_config.py
index 8cea64350..a8488f5e4 100644
--- a/tests/addons/test_config.py
+++ b/tests/addons/test_config.py
@@ -70,3 +70,87 @@ def test_valid_basic_build():
     config = load_json_fixture("basic-build-config.json")
 
     vd.SCHEMA_BUILD_CONFIG(config)
+
+
+def test_valid_machine():
+    """Validate valid machine config."""
+    config = load_json_fixture("basic-addon-config.json")
+
+    config["machine"] = [
+        "intel-nuc",
+        "odroid-c2",
+        "odroid-n2",
+        "odroid-xu",
+        "qemuarm-64",
+        "qemuarm",
+        "qemux86-64",
+        "qemux86",
+        "raspberrypi",
+        "raspberrypi2",
+        "raspberrypi3-64",
+        "raspberrypi3",
+        "raspberrypi4-64",
+        "raspberrypi4",
+        "tinker",
+    ]
+
+    assert vd.SCHEMA_ADDON_CONFIG(config)
+
+    config["machine"] = [
+        "!intel-nuc",
+        "!odroid-c2",
+        "!odroid-n2",
+        "!odroid-xu",
+        "!qemuarm-64",
+        "!qemuarm",
+        "!qemux86-64",
+        "!qemux86",
+        "!raspberrypi",
+        "!raspberrypi2",
+        "!raspberrypi3-64",
+        "!raspberrypi3",
+        "!raspberrypi4-64",
+        "!raspberrypi4",
+        "!tinker",
+    ]
+
+    assert vd.SCHEMA_ADDON_CONFIG(config)
+
+    config["machine"] = [
+        "odroid-n2",
+        "!odroid-xu",
+        "qemuarm-64",
+        "!qemuarm",
+        "qemux86-64",
+        "qemux86",
+        "raspberrypi",
+        "raspberrypi4-64",
+        "raspberrypi4",
+        "!tinker",
+    ]
+
+    assert vd.SCHEMA_ADDON_CONFIG(config)
+
+
+def test_invalid_machine():
+    """Validate invalid machine config."""
+    config = load_json_fixture("basic-addon-config.json")
+
+    config["machine"] = [
+        "intel-nuc",
+        "raspberrypi3",
+        "raspberrypi4-64",
+        "raspberrypi4",
+        "tinkerxy",
+    ]
+
+    with pytest.raises(vol.Invalid):
+        assert vd.SCHEMA_ADDON_CONFIG(config)
+
+    config["machine"] = [
+        "intel-nuc",
+        "intel-nuc",
+    ]
+
+    with pytest.raises(vol.Invalid):
+        assert vd.SCHEMA_ADDON_CONFIG(config)